ZEOPHARM® 5170 is a high-purity, hydrophilic milled precipitated silica powder engineered as a high-performance adsorptive carrier for pharmaceutical, nutraceutical and premium personal care applications. Manufactured by Evonik Operations GmbH under GMP-aligned production conditions, this material is purpose-built to convert liquid active pharmaceutical ingredients (APIs), oily excipients, botanical extracts and functional liquids into free-flowing, accurately dosable powder forms, with full regulatory alignment for major global markets.

As the pharmaceutical-grade counterpart to Evonik's ZEOFREE® 5170 food-grade carrier, ZEOPHARM® 5170 delivers equivalent core adsorption performance with elevated purity controls and pharmacopoeia compliance, making it suitable for oral solid dosage forms, liquisolid delivery systems and direct-compression tablet manufacturing.

Independent pharmaceutical formulation research has characterized ZEOPHARM® 5170 for solid-dosage processability, confirming exceptional flow behavior that supports high-speed manufacturing:

· Apparent (untamped) bulk density: 0.32 g/cm³

· Tapped density: 0.34 g/cm³

· Carr's Compressibility Index: 6.2 % – classified as excellent flowability

· Hausner Ratio: 1.07 – indicates very low interparticle cohesion and minimal segregation risk

· Flow orifice diameter (Copley test): 4 mm – top-tier flow grade for powder carriers

· Compact hardness (Wells test): 15–16 N at standard compaction force

These properties establish ZEOPHARM® 5170 as a benchmark carrier for liquisolid tablet technology, where it outperforms alternative silicate carriers in blend uniformity and processing consistency for BCS Class II poorly soluble drugs.

ZEOPHARM® 5170 is manufactured to meet worldwide quality and safety standards, supporting product registration across North America, Europe, Asia-Pacific and emerging markets:

· Quality Systems: Produced under GMP conditions; manufacturing sites certified to ISO 9001

· Pharmacopoeia Compliance: Conforms to USP/NF (United States Pharmacopeia / National Formulary) Silicon Dioxide monograph and Ph. Eur. (European Pharmacopoeia) Silicon Dioxide monograph

· Food & Feed Standards: Meets EU Regulation (EU) 231/2012 purity criteria for E 551 (precipitated silica); aligned with FDA 21 CFR provisions for food-contact applications

· Cosmetics Compliance: Meets COSMOS standard requirements for natural and organic cosmetic ingredients

· Dietary & Religious Certifications: Certified Kosher (Pareve), Kosher for Passover, and Halal

· Origin Statement: 100% synthetic amorphous silica; no animal-derived raw materials, suitable for vegan and vegetarian formulations

1. Reliable Liquid-to-Powder Conversion High pore volume and adsorption capacity enable uniform loading of liquid APIs, essential oils, herbal extracts and viscous excipients, converting them into free-flowing powders with precise dose consistency.

2. Superior Process Efficiency Industry-leading flow characteristics reduce blend segregation, improve fill weight uniformity, and enable higher throughput in tableting, encapsulation and powder-filling operations, with shorter cycle times and lower material loss.

3. Chemical Inertness & Sensory Neutrality Chemically inert amorphous silica does not interact with active ingredients. The product is tasteless and odorless, preserving the original flavor, therapeutic activity and stability profile of loaded actives.

4. Improved Occupational Safety Converts corrosive, acidic or skin-irritant liquid components into dry powder form, reducing spill risk, minimizing worker exposure and simplifying plant handling, storage and transport protocols.

5. Long-Term Formulation Stability Inherent chemical stability preserves loaded active integrity over shelf life; controlled porous structure supports consistent release performance in finished dosage forms.

· Pharmaceutical Oral Solids: Liquisolid tablets for poorly water-soluble APIs, direct-compression tablet blends, powder-filled hard capsules, and granulation processing aids

· API & Excipient Carrier Systems: Adsorption of liquid drug substances, oily active concentrates, softgel fill materials and liquid lubricants into dry, handleable powder formats

· Nutraceuticals & Functional Nutrition: Loading of plant extracts, omega-3 oils, herbal concentrates, liposomal actives and vitamin liquids into free-flowing powder premixes

· Premium Personal Care: High-purity carrier for powdered skincare actives, dry shampoo formulations, and powder cosmetic bases

· Industrial Pharma Processing: Flow aid, anti-caking agent and processing aid for bulk powder blending, spray-drying post-processing and continuous manufacturing lines

Comprehensive hazard, exposure and first-aid information is documented in the official Safety Data Sheet (SDS), provided with first shipment or available upon request from Evonik Product Safety.

· Use with adequate local exhaust ventilation to control respirable dust levels

· Standard PPE (safety eyewear, dust mask, protective gloves) is recommended for bulk handling operations

· The material is chemically inert with very low acute toxicity (oral LD₅₀ > 10,000 mg/kg in rats)

· Avoid generation and accumulation of fine dust deposits in work areas

· Packaging: Supplied in standard industrial bulk packaging; custom package sizes and formats are available through local Evonik sales channels.

· Storage Conditions: Store in original, fully sealed packaging or airtight closed containers in a cool, dry environment. Keep away from volatile organic substances, as high specific surface area may lead to adsorption of ambient vapors.

· Shelf Life: 36 months from date of manufacture under recommended storage conditions. Material held beyond 36 months should be tested for moisture content prior to use to verify compliance with application requirements.

EMEA / Latin America Evonik Operations GmbH, Business Line Silica Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang, Germany Phone: +49 6181 59-3536 Fax: +49 6181 59-4096 Email: ask-si@evonik.com

North America Evonik Corporation, Commercial Silica 299 Jefferson Road, Parsippany, NJ 07054-0677, USA Phone: +1 800 233-8052 Fax: +1 973 929-8502 Email: ask-si@evonik.com

Asia Pacific Evonik (SEA) Pte Ltd, Commercial Silica 3 International Business Park, #07-18 Nordic European Centre Singapore 609927 Phone: +65 6 809 6877 Fax: +65 6 809 6677 Email: ask-si-asia@evonik.com