Enhance Pharmaceutical Solutions with Grace SYLOID® 244 FP: Versatile Silica for Drug Formulation, Stability, and Optimization

Created on 06.29

The application of Grace SYLOID® 244 FP silica in the pharmaceutical field is centered on its core advantages of high adsorption capacity, mesoporous structure, and extensive compliance, covering multiple links from pharmaceutical formulation development to production process optimization. The following are its specific application scenarios and technical details:

I. Solid Carrier for Liquid Drugs

1. Solid Dispersions of Oily APIs

Technical Principle
Application Cases

Sulfathiazole: When combined with Plasdone® K-29/32 to prepare solid dispersions, the drug dissolution rate is increased by 3 times, solving the problem of slow dissolution of traditional physical mixtures.
Cinnamon oil: In cooperation with Tianjin Medical University, 244FP is used to stabilize natural active ingredients, providing support for the development of new drug carriers.

Dosage Form Adaptability

2. Stabilization of Liposomes and Nanosuspensions

Function Expansion
Process Advantage

II. Formulation Stability Enhancement Solutions

1. Protection of Humidity-Sensitive Drugs

Mechanism of Action
Experimental Data
Compatibility Advantage

2. Moisture-Resistant Coating and Anti-Adhesion

Coating Application
Technical Parameters

III. Key Excipients for Production Process Optimization

1. Improvement of Flowability in Direct Compression

Powder Characteristics
Tableting Data

2. Suspending and Thickening of Suspensions and Ointments

Rheological Properties
Application Scenarios

IV. Emerging Fields and Cutting-Edge Research

1. Botanical Drugs and Probiotic Preparations

Probiotic Protection
Retention of Botanical Drug Activity

2. Development of New Drug Delivery Systems

Sustained and Controlled Release
Topical Administration

V. Compliance and Quality Assurance

Regulatory Support
Production Advantage

Summary

Grace SYLOID® 244 FP has become a "versatile player" in the pharmaceutical field through its triple mechanism of adsorption, stabilization, and efficiency enhancement. Its performance in liquid drug solidification, moisture-proof protection, and process optimization has been widely verified, especially showing unique value in the development of natural drugs, probiotics, and new formulations. For customized solutions, please refer to Grace's official technical documents or contact its global technical service team.

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