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Colloidal silica (medicinal excipients) summary list, one read colloidal silica
2024.12.27
Colloidal silica (medicinal excipients) summary list, one read colloidal silica
Chinese Name
Colloidal Silicon Dioxide
English Name
Colloidal silica (medicinal excipients)
Chinese Synonym
Micropowdered Silica Gel
English Synonyms
Aerosil; colloidal silica; fumed silica; fumed silicon dioxide; hochdisperses silicum dioxid; SAS; silica colloidalis anhydrica; silica sol; silicic anhydride; silicon dioxide colloidal; silicon dioxide fumed; synthetic amorphous silica; Wacker HDK
Chemical Name
Silica
CAS Registry Number
7631-86-9
Molecular Formula
SiO₂
Molecular Weight
60.08
Structural Formula
None
Classification
Viscosity Increasing Agent; Suspending Agent
Uses
Widely used in pharmaceuticals, cosmetics and food. It can improve the fluidity of dry powder (such as tabletting), stabilize emulsions, act as a thixotropic thickening agent and suspending agent in gel and semi-solid preparations, form a transparent gel with components having similar refractive indices, and its viscosity is affected by the polarity of the liquid and the pH of the system. In non-inhalation aerosol preparations, it is often used to promote the suspension of particles, prevent the formation of hard precipitates and reduce nozzle clogging. It can also be used as a disintegrant for tablets, an adsorbent dispersant for powders, and a viscosity increasing agent for suppositories containing lipophilic matrices
Routes of Administration
Oral, inhalation, transdermal, sublingual, vaginal
Safety
Widely used in oral and some topical preparations, generally considered non-toxic and non-irritating. However, intraperitoneal and subcutaneous injections may cause local tissue necrosis and granuloma, so silica is not suitable for injection. LD50 (rat, IV): 15mg/kg; LD50 (rat, oral): 3.16g/kg
Contraindications
Incompatible with Diethylstilbestrol
Source and Preparation
Prepared by gas-phase hydrolysis of chlorosilanes, for example, using silicon tetrachloride and burning it with hydrogen and oxygen flames at 1800℃
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